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PD-166866 is a potent inhibitor of FGFR autophosphorylation in NIH 3T3 cells expressing endogenous FGFR-1 and in L6 cells overexpressing the human FGFR-1 tyrosine kinase
25 mg/kg/day
Molecular Weight: 377
It was isolated in 1949 from the microbial organism Aspergillus fumigatus
Tetrodotoxin is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (NaV) channels
AMG 487 - CAS# 473719-41-4 Catalog No.:M10194-2 PD-166866 is a potent inhibitorAMG 487 is a potent and selective antagonist of chemokine (C X C motif) receptor 3 (CXCR3) with IC50 values of 8nM and 8. 2nM for I IP 10 and I ITAC, respectively. AMG 487 prevents the chemokines I IP 10 and I ITAC from binding to CXCR3. In the cellular assays, AMG 487 inhibits CXCR3 mediated cell migration with IC50 values of 8nM, 15nM and 36nM for I IP 10, I ITAC and MIG, respectively. Product information CAS Number: 473719 41 4 Molecular Weight: