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NS-638 administered i
and p-4E-BP1) and mTOR complex 2 (pAKT (S473)) substrates
InChi: InChI=1S/C22H21F3N6O2/c1-5-18(32)28-17-8-12(2)6-7-15(17)29-20-14(22(23
1-1000 nM) elicits Ca2+ influx in mouse and human TRPV4-expressing human embryonic kidney (HEK) cells (EC50 values of 18 and 2
5-fold less sensitive than ALK5) but does not inhibit ALK2 at concentrations up to 10 μM
DD-03-156 ope muscari NS-638 administered iDD 03 156 is a potent and selective degrader of CDK17 and LIMK2. The selectivity and potency of DD 03 156 is exquisite and makes an advanced starting point for the development of a chemical probe for the degradation of CDK17. Product information Molecular Weight: 1106. 31 Formula: C53H62F3N9O8S3 Smiles:
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