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InChiKey: JYGXADMDTFJGBT-VWUMJDOOSA-N
InChiKey: MALFODICFSIXPO-KFKQDBFTSA-N
Smiles: CC1N=C(N)SC=1C1=CC=NC(NC2C=CC(=CC=2)N2CCOCC2)=N1
is a nonsteroidal glucocorticoid receptor antagonist
2Na/c8-7(9)5-1-3-6(4-2-5)13-14(10
Ruxolitinib sulfate - CAS# 1092939-16-6 alog 2 InChiKey: JYGXADMDTFJGBT-VWUMJDOOSA-NRuxolitinib sulfate is the first potent, selective JAK1 2 inhibitor to enter the clinic with IC50s of 3. 3 nM 2. 8 nM, and has > 130 fold selectivity for JAK1 2 versus JAK3. Ruxolitinib potently and selectively inhibits JAK2V617F mediated signaling and proliferation, markedly increases apoptosis in a dose dependent manner, and at 64 nM results in a doubling of cells with depolarized mitochondria in Ba F3 cells. Ruxolitinib demonstrates remarkable
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