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Solubility: DMSO : 50 mg/mL (69
Inhibition of HERG potassium channels by the antimalarial agent halofantrine
This natural product inhibits the phosphorylation and translocation of both STAT3 and NF-κB
InChi: InChI=1S/2C29H25N3O7/c1-30(2)17-6-9-20-23(14-17)38-24-15-18(31(3)4)7-10-21(24)27(20)22-13-16(5-8-19(22)28(35)36)29(37)39-32-25(33)11-12-26(32)34
also known as MK-8776
PF-3758309 hydrochloride Size:Contact [email protected] for quotation Solubility: DMSO : 50 mg/mLPF 3758309 hydrochloride is a potent, orally available, and reversible ATP competitive inhibitor of PAK4 (Kd= 2. 7 nM; Ki=18. 7 nM). PF 3758309 hydrochloride has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation. Product information CAS Number: 1279034 84 2 Molecular Weight: 527. 08 Formula: C25H31ClN8OS Chemical Name: (S) N